Dear California Idrasil Patient,

If you suffer from Nausea and take Zofran / Ondansetron or Phenergan / Promethazine, please know that you have the right to a natural, Safe-Choice.

Natural Vs. Chemical

Please understand that all drugs are pharmaceutically known as ‘single-molecule’ chemicals. They are inherently, not Natural. The term ‘Single-molecule’ is a chemical standard which means the drug has been manufactured in a replicable process, in a pharmaceutical-grade laboratory. Natural medicines are similarly manufactured and have been actively removed from the traditional ‘U.S. Pharmacopeia’, in the 1930’s, favoring the ‘Physicians Desk Reference’ (PDR). The PDR solely lists chemicals that are approved only by the FDA, via its’ discriminatory ‘clinical trials’ (INDA) process. Natural medicines are not allowed to be referred to as ‘Drugs’; They are classified as ‘medicinal-food’, ‘dietary-supplements’ or ‘nutraceuticals’. Natural, plant-based medicines have always existed and still perform safely and effectively, throughout human history, globally.

Natural Remedies ARE God’s Medicine

When faced with an ailment, it is imperative to know that you have two (2) options:

1. Choose a Natural Remedy, First.

‘Single-molecule’ chemicals have many dangerous and toxic side effects; Often including organ failure and death. Using a natural option first, is the smart and harm-reductive measure. Idrasil for Quality of Life (QoL).

Why take unnecessary Risk?
Many people find easy, natural relief and avoid the toxicity of chemical drugs by using a nutraceutical, first. If you do not find satisfactory relief with Idrasil, you still have a reserved option:

2. An unnatural, synthetic, single-molecule drug and risk its’ side-effects. Drugs’ efficacy of which is often marginal, when compared to its risks.

Bottom line: Big-pharma does not want you to know that you have 2 medicinal source options: Plant-based or Synthetic. Natural or Chemical.

U.S. society has been conditioned such that when we go to the doctor, we are given our prescription and then fail to read the long, thin paper insert, with the tiny print, that tells you the multitude of ways this drug could harm or, even kill you. Google ‘Meaning of Black Box Warning’. Knowledge is Power. Ever noticed how during TV drug ads, they stealthily down-modulate the voice, obscuring all the harmful side effects?

You’re not supposed to hear the negative side-effects! Rather, remember the drug name, visit their website and always “Ask Your Doctor”.

Always, Ask Your Doctor for Idrasil, First!

Prescribers Sig Idrasil 25Mg, PRN for QoL.

© C3® 2020

The post A C3® OPEN LETTER appeared first on Idrasil® RX.

Dear California Idrasil Patient,

If you suffer from Schizophrenia and take Abilify / Aripiprazole, Fanapt / Iloperidone, Latuda / Lurasidone, Rexulti / Brexpiprazole or Vraylar / Cariprazine, please know that you have the right to a natural, Safe-Choice.

Natural Vs. Chemical

Please understand that all drugs are pharmaceutically known as ‘single-molecule’ chemicals. They are inherently, not Natural. The term ‘Single-molecule’ is a chemical standard which means the drug has been manufactured in a replicable process, in a pharmaceutical-grade laboratory. Natural medicines are similarly manufactured and have been actively removed from the traditional ‘U.S. Pharmacopeia’, in the 1930’s, favoring the ‘Physicians Desk Reference’ (PDR). The PDR solely lists chemicals that are approved only by the FDA, via its’ discriminatory ‘clinical trials’ (INDA) process. Natural medicines are not allowed to be referred to as ‘Drugs’; They are classified as ‘medicinal-food’, ‘dietary-supplements’ or ‘nutraceuticals’. Natural, plant-based medicines have always existed and still perform safely and effectively, throughout human history, globally.

Natural Remedies ARE God’s Medicine

When faced with an ailment, it is imperative to know that you have two (2) options:

1. Choose a Natural Remedy, First.

‘Single-molecule’ chemicals have many dangerous and toxic side effects; Often including organ failure and death. Using a natural option first, is the smart and harm-reductive measure. Idrasil for Quality of Life (QoL).

Why take unnecessary Risk?
Many people find easy, natural relief and avoid the toxicity of chemical drugs by using a nutraceutical, first. If you do not find satisfactory relief with Idrasil, you still have a reserved option:

2. An unnatural, synthetic, single-molecule drug and risk its’ side-effects. Drugs’ efficacy of which is often marginal, when compared to its risks.

Bottom line: Big-pharma does not want you to know that you have 2 medicinal source options: Plant-based or Synthetic. Natural or Chemical.
U.S. society has been conditioned such that when we go to the doctor, we are given our prescription and then fail to read the long, thin paper insert, with the tiny print, that tells you the multitude of ways this drug could harm or, even kill you. Google ‘Meaning of Black Box Warning’. Knowledge is Power. Ever noticed how during TV drug ads, they stealthily down-modulate the voice, obscuring all the harmful side effects?

You’re not supposed to hear the negative side-effects! Rather, remember the drug name, visit their website and always “Ask Your Doctor”.

Always, Ask Your Doctor for Idrasil, First!

Prescribers Sig Idrasil 25Mg, PRN for QoL.

© C3® 2020

The post A C3® OPEN LETTER appeared first on Idrasil® RX.

Dear California Idrasil Patient,

If you suffer from the pain of Migraine and take Aimovig / Erenumab-aooe, Emgality / Galcanezumab-gnlm, Nurtek ODT / Rimegepant, Ubrelvy – Ubrogepant or Voltaren / Diclofenac, please know that you have the right to a natural, Safe-Choice.

Natural Vs. Chemical

Please understand that all drugs are pharmaceutically known as ‘single-molecule’ chemicals. They are inherently, not Natural. The term ‘Single-molecule’ is a chemical standard which means the drug has been manufactured in a replicable process, in a pharmaceutical-grade laboratory. Natural medicines are similarly manufactured and have been actively removed from the traditional ‘U.S. Pharmacopeia’, in the 1930’s, favoring the ‘Physicians Desk Reference’ (PDR). The PDR solely lists chemicals that are approved only by the FDA, via its’ discriminatory ‘clinical trials’ (INDA) process. Natural medicines are not allowed to be referred to as ‘Drugs’; They are classified as ‘medicinal-food’, ‘dietary-supplements’ or ‘nutraceuticals’. Natural, plant-based medicines have always existed and still perform safely and effectively, throughout human history, globally.

Natural Remedies ARE God’s Medicine

When faced with an ailment, it is imperative to know that you have two (2) options:

1. Choose a Natural Remedy, First.

‘Single-molecule’ chemicals have many dangerous and toxic side effects; Often including organ failure and death. Using a natural option first, is the smart and harm-reductive measure. Idrasil for Quality of Life (QoL).

Why take unnecessary Risk?

Many people find easy, natural relief and avoid the toxicity of chemical drugs by using a nutraceutical, first. If you do not find satisfactory relief with Idrasil, you still have a reserved option:

2. An unnatural, synthetic, single-molecule drug and risk its’ side-effects. Drugs’ efficacy of which is often marginal, when compared to its risks.

Bottom line: Big-pharma does not want you to know that you have 2 medicinal source options: Plant-based or Synthetic. Natural or Chemical.

U.S. society has been conditioned such that when we go to the doctor, we are given our prescription and then fail to read the long, thin paper insert, with the tiny print, that tells you the multitude of ways this drug could harm or, even kill you. Google ‘Meaning of Black Box Warning’. Knowledge is Power. Ever noticed how during TV drug ads, they stealthily down-modulate the voice, obscuring all the harmful side effects?

You’re not supposed to hear the negative side-effects! Rather, remember the drug name, visit their website and always “Ask Your Doctor”.

Always, Ask Your Doctor for Idrasil, First!

Prescribers Sig Idrasil 25Mg, PRN for QoL.

© C3® 2020

The post A C3® OPEN LETTER appeared first on Idrasil® RX.

Dear California Idrasil Patient,

If you suffer from the pain, discomfort and bloated feeling associated with chronic Ulcerative Colitis, Crohn’s Disease or I.B.S., and take Entyvio/ Vesizumab or Stelara/ Ustekinumab, please know that you have the right to a natural, Safe-Choice.

Natural Vs. Chemical

Please understand that all drugs are pharmaceutically known as ‘single-molecule’ chemicals. They are inherently, not Natural. The term ‘Single-molecule’ is a chemical standard which means the drug has been manufactured in a replicable process, in a pharmaceutical-grade laboratory. Natural medicines are similarly manufactured and have been actively removed from the traditional ‘U.S. Pharmacopeia’, in the 1930’s, favoring the ‘Physicians Desk Reference’ (PDR). The PDR solely lists chemicals that are approved only by the FDA, via its’ discriminatory ‘clinical trials’ (INDA) process. Natural medicines are not allowed to be referred to as ‘Drugs’; They are classified as ‘medicinal-food’, ‘dietary-supplements’ or ‘nutraceuticals’. Natural, plant-based medicines have always existed and still perform safely and effectively, throughout human history, globally.

Natural Remedies ARE God’s Medicine

When faced with an ailment, it is imperative to know that you have two (2) options:

1. Choose a Natural Remedy, First.

‘Single-molecule’ chemicals have many dangerous and toxic side effects; Often including organ failure and death. Using a natural option first, is the smart and harm-reductive measure. Idrasil for Quality of Life (QoL).

Why take unnecessary Risk?

Many people find easy, natural relief and avoid the toxicity of chemical drugs by using a nutraceutical, first. If you do not find satisfactory relief with Idrasil, you still have a reserved option:

2. An unnatural, synthetic, single-molecule drug and risk its’ side-effects. Drugs’ efficacy of which is often marginal, when compared to its risks.

Bottom line: Big-pharma does not want you to know that you have 2 medicinal source options: Plant-based or Synthetic. Natural or Chemical.

U.S. society has been conditioned such that when we go to the doctor, we are given our prescription and then fail to read the long, thin paper insert, with the tiny print, that tells you the multitude of ways this drug could harm or, even kill you. Google ‘Meaning of Black Box Warning’. Knowledge is Power. Ever noticed how during TV drug ads, they stealthily down-modulate the voice, obscuring all the harmful side effects?

You’re not supposed to hear the negative side-effects! Rather, remember the drug name, visit their website and always “Ask Your Doctor”.

Always, Ask Your Doctor for Idrasil, First!

Prescribers Sig Idrasil 25Mg, PRN for QoL.

© C3® 2020

The post A C3® OPEN LETTER appeared first on Idrasil® RX.

Dear California Idrasil Patient,

If you suffer from the pain, discomfort and embarrassment associated with chronic Eczema, Psoriasis, Plaque Psoriasis or Psoriatic Arthritis and take Dupixent, Inj. – Dupilumab / Otezla – Apremilast / Cosentyx – Secukinumab / Humira – Adalimumab / Siliq, Injection – Brodalumab/ Rinvoq – Upadacitinib / Skyrizi – Risankizumab-rzaa / Enbrel – Entanercept / Xeljanz – Tofacitnib / Ilumya – Tildrakizumab / Taltz – Ixekizumab or Tremfya – Guselkumab, please know that you have the right to a natural, Safe-Choice.

Natural Vs. Chemical

Please understand that all drugs are pharmaceutically known as ‘single-molecule’ chemicals. They are inherently, not Natural. The term ‘Single-molecule’ is a chemical standard which means the drug has been manufactured in a replicable process, in a pharmaceutical-grade laboratory. Natural medicines are similarly manufactured and have been actively removed from the traditional ‘U.S. Pharmacopeia’, in the 1930’s, favoring the ‘Physicians Desk Reference’ (PDR). The PDR solely lists chemicals that are approved only by the FDA, via its’ discriminatory ‘clinical trials’ (INDA) process. Natural medicines are not allowed to be referred to as ‘Drugs’; They are classified as ‘medicinal-food’, ‘dietary-supplements’ or ‘nutraceuticals’. Natural, plant-based medicines have always existed and still perform safely and effectively, throughout human history, globally.

Natural Remedies ARE God’s Medicine

When faced with an ailment, it is imperative to know that you have two (2) options:

1. Choose a Natural Remedy, First.

‘Single-molecule’ chemicals have many dangerous and toxic side effects; Often including organ failure and death. Using a natural option first, is the smart and harm-reductive measure. Idrasil for Quality of Life (QoL).

Why take unnecessary Risk?

Many people find easy, natural relief and avoid the toxicity of chemical drugs by using a nutraceutical, first. If you do not find satisfactory relief with Idrasil, you still have a reserved option:

2. An unnatural, synthetic, single-molecule drug and risk its’ side-effects. Drugs’ efficacy of which is often marginal, when compared to its risks.

Bottom line: Big-pharma does not want you to know that you have 2 medicinal source options: Plant-based or Synthetic. Natural or Chemical.

U.S. society has been conditioned such that when we go to the doctor, we are given our prescription and then fail to read the long, thin paper insert, with the tiny print, that tells you the multitude of ways this drug could harm or, even kill you. Google ‘Meaning of Black Box Warning’. Knowledge is Power. Ever noticed how during TV drug ads, they stealthily down-modulate the voice, obscuring all the harmful side effects?

You’re not supposed to hear the negative side-effects! Rather, remember the drug name, visit their website and always “Ask Your Doctor”.

Always, Ask Your Doctor for Idrasil, First!

Prescribers Sig Idrasil 25Mg, PRN for QoL.

© C3® 2020

The post A C3® OPEN LETTER appeared first on Idrasil® RX.

Two primary endocannabinoid receptors have been identified: CB1, first cloned in 1990; and CB2, cloned in 1993. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), anandamide, as well as its mimeticphytocannabinoid, THC. One other main endocannabinoid is 2-arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD. 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management.^[10][11][12]

The endocannabinoid system, broadly speaking, includes:

• The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as “endocannabinoids” and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids.^[13]
• The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase.
• The cannabinoid receptors CB₁ and CB₂, two G protein-coupled receptors that are located in the central and peripheral nervous systems.

The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized collectively comprise the endocannabinoid system.

The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators^[14][15][16] for a variety of processes, including motor learning,^[17] appetite,^[18] and pain sensation,^[19] among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive.^[20]Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system,^[20][21] where the CB1 and orexin receptor 1(OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.^[20][22][23]

Expression of receptors

Cannabinoid binding sites exist throughout the central and peripheral nervous systems. The two most relevant receptors for cannabinoids are the CB₁ and CB₂ receptors, which are expressed predominantly in the brain and immune system respectively.^[24] Density of expression varies based on species and correlates with the efficacy that cannabinoids will have in modulating specific aspects of behavior related to the site of expression. For example, in rodents, the highest concentration of cannabinoid binding sites are in the basal gangliaand cerebellum, regions of the brain involved in the initiation and coordination of movement.^[25] In humans, cannabinoid receptors exist in much lower concentration in these regions, which helps explain why cannabinoids possess a greater efficacy in altering rodent motor movements than they do in humans.

A recent analysis of cannabinoid binding in CB₁ and CB₂ receptor knockout mice found cannabinoid responsiveness even when these receptors were not being expressed, indicating that an additional binding receptor may be present in the brain.^[25] Binding has been demonstrated by 2-arachidonoylglycerol (2-AG) on the TRPV1 receptor suggesting that this receptor may be a candidate for the established response.^[26]

In addition to CB1 and CB2, certain orphan receptors are known to bind endocannabinoids as well, including GPR18, GPR55 (a regulator of neuroimmune function), and GPR119. CB1 has also been noted to form a functional human receptor heterodimer in orexin neurons with OX1, the CB1–OX1 receptor, which mediates feeding behavior and certain physical processes such as cannabinoid-induced pressor responses which are known to occur through signaling in the rostral ventrolateral medulla.^[27][28]

Endocannabinoid synthesis, release, and degradation

During neurotransmission, the pre-synaptic neuron releases neurotransmitters into the synaptic cleft which bind to cognate receptors expressed on the post-synaptic neuron. Based upon the interaction between the transmitter and receptor, neurotransmitters may trigger a variety of effects in the post-synaptic cell, such as excitation, inhibition, or the initiation of second messenger cascades. Based on the cell, these effects may result in the on-site synthesis of endogenous cannabinoids anandamide or 2-AG by a process that is not entirely clear but results from an elevation in intracellular calcium.^[24] Expression appears to be exclusive so that both types of endocannabinoids are not co-synthesized. This exclusion is based on synthesis-specific channel activation: a recent study found that in the bed nucleus of the stria terminalis, calcium entry through voltage-sensitive calcium channels produced an L-type current resulting in 2-AG production, while activation of mGluR1/5 receptors triggered the synthesis of anandamide.^[26]

Evidence suggests that the depolarization-induced influx of calcium into the post-synaptic neuron causes the activation of an enzyme called transacylase. This enzyme is suggested to catalyze the first step of endocannabinoid biosynthesis by converting phosphatidylethanolamine, a membrane-resident phospholipid, into N-acyl-phosphatidylethanolamine(NAPE). Experiments have shown that phospholipase D cleaves NAPE to yield anandamide.^[29][30] This process is mediated by bile acids.^[31] In NAPE-phospholipase D (NAPEPLD)-knockout mice, cleavage of NAPE is reduced in low calcium concentrations, but not abolished, suggesting multiple, distinct pathways are involved in anandamide synthesis.^[32] The synthesis of 2-AG is less established and warrants further research.

Once released into the extracellular space by a putative endocannabinoid transporter, messengers are vulnerable to glial cell inactivation. Endocannabinoids are taken up by a transporter on the glial cell and degraded by fatty acid amide hydrolase (FAAH), which cleaves anandamide into arachidonic acid and ethanolamine or monoacylglycerol lipase(MAGL), and 2-AG into arachidonic acid and glycerol.^[33] While arachidonic acid is a substrate for leukotriene and prostaglandin synthesis, it is unclear whether this degradative byproduct has unique functions in the central nervous system.^[34][35] Emerging data in the field also points to FAAH being expressed in postsynaptic neurons complementary to presynaptic neurons expressing cannabinoid receptors, supporting the conclusion that it is major contributor to the clearance and inactivation of anandamide and 2-AG after endocannabinoid reuptake.^[25] A neuropharmacological study demonstrated that an inhibitor of FAAH (URB597) selectively increases anandamide levels in the brain of rodents and primates. Such approaches could lead to the development of new drugs with analgesic, anxiolytic-like and antidepressant-like effects, which are not accompanied by overt signs of abuse liability.^[36]

Binding and intracellular effects

Cannabinoid receptors are G-protein coupled receptors located on the pre-synaptic membrane. While there have been some papers that have linked concurrent stimulation of dopamine and CB₁ receptors to an acute rise in cyclic adenosine monophosphate (cAMP) production, it is generally accepted that CB₁ activation via cannabinoids causes a decrease in cAMP concentration by inhibition of adenylyl cyclase and a rise in the concentration of mitogen-activated protein kinase (MAP kinase).^[13][25] The relative potency of different cannabinoids in inhibition of adenylyl cyclase correlates with their varying efficacy in behavioral assays. This inhibition of cAMP is followed by phosphorylation and subsequent activation of not only a suite of MAP kinases (p38/p42/p44), but also the PI3/PKB and MEK/ERK pathway (Galve-Roperh et al., 2002; Davis et al., 2005; Jones et al., 2005; Graham et al., 2006). Results from rat hippocampal gene chip data after acute administration of tetrahydrocannabinol (THC) showed an increase in the expression of transcripts encoding myelin basic protein, endoplasmic proteins, cytochrome oxidase, and two cell adhesion molecules: NCAM, and SC1; decreases in expression were seen in both calmodulin and ribosomal RNAs (Kittler et al., 2000). In addition, CB1 activation has been demonstrated to increase the activity of transcription factors like c-Fos and Krox-24(Graham et al., 2006).

Source: https://en.wikipedia.org/wiki/Endocannabinoid_system

The post EndoCannabinoid System appeared first on Idrasil® RX.

Could cannabis be part of the solution? Quite possibly. An increasing number of studies provide evidence that many patients can use cannabis instead of opioids to treat their pain, or they can significantly reduce their reliance on opioids.

A University of Michigan March 2016 study published in the Journal of Pain provides some compelling data. They found that cannabis:

• Decreased side effects from other medications
• Improved quality of life
• Reduced use of opioids (on average) by 64%

“We are learning that the higher the dose of opioids people are taking, the higher the risk of death from overdose,” said Dr. Daniel Clauw, one of the study’s researchers and a professor of pain management anesthesiology at the University of Michigan Medical School. “[The] magnitude of reduction in our study is significant enough to affect an individual’s risk of accidental death from overdose.”

Kevin Ameling, a chronic pain patient who now works for a Colorado-based non-profit cannabis research advocacy group called the IMPACT Network, is a success story. Ameling believes cannabis saved him from a life of dependency on prescription drugs. In 2007, he suffered a severe fall and was prescribed a cocktail of prescription drugs that included OxyContin, Tramadol, Clonazepam, and Lexapro. The pain became so severe that he had to progressively increase dosage while the OxyContin became less and less effective.

Living in Colorado, he decided to try medical marijuana in 2013. He claims he achieved results immediately and was able to significantly reduce his prescription intake. He cut his OxyContin dosage by 50%, reduced Clonazepam from 3 mg to 0.5 mg, Lexapro from 30 mg to 5 mg, and Tramadol from 300 mg to 75 mg.

“It’s hard to express in words what a life changer medical marijuana has been for me,” said Ameling. “I was becoming increasingly worried about having to take higher doses of prescription drugs that can be highly addictive and toxic. Not only was I able to cut back significantly, with cannabis I can often skip the OxyContin with no adverse effects, something I couldn’t do before.”

Try Idrasil to reduce pain today. Learn more here

Source: https://www.leafly.com/news/health/cannabis-for-chronic-pain-vs-opioids

The post Cannabis vs Opioids appeared first on Idrasil® RX.